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Winston Churchill even once declared,
“The gin and tonic drink has saved more Englishmen’s lives, and minds, than all the doctors in the Empire.”

India: the jewel of the British Empire. While Britain colonized this vast country throughout the 19th century, a large part of travelers and colonists suffered from malaria. The fever has a history of ravaging scores of Europeans, but in the 17th century the Spanish discovered that indigenous peoples in present-day Peru used a bark to treat various fevers. A stolen cinchona bark became a favored treatment for malaria in Europe. It was soon learned that it not only treated malaria, it worked preventatively.

Gin and Tonic History


The active ingredient within the bark, quinine, became a powerful weapon for the British Empire, as it allowed its soldiers to rule in distant lands. However, there was one problem. Quinine powder was intensely bitter and hard to swallow. Naturally, the Brits diluted it in sugar water and “tonic water” in its earliest form was born.

 
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But that operates under the false premise that both sides of that zig-zag equation are operating with the same levels of expertise.

If I'm dying or have a family member or friend dying of this then I'm willing to try anything and absolutely would expect that be the case with anyone.

This stuff is just being wayyyyyy oversold right now without any acceptable level of proof and that's both dangerous on many fronts and providing a false sense of security/hope where it shouldn't.

If anything is being oversold, it's this pandemic that's being peddled by the media in order to cripple our economy. But you keep on *****ing about so called cures for a so called pandemic that's being spun in whatever direction the talking heads deem necessary in the 24/7 news cycle.

Go Canes!!!
 
If anything is being oversold, it's this pandemic that's being peddled by the media in order to cripple our economy. But you keep on *****ing about so called cures for a so called pandemic that's being spun in whatever direction the talking heads deem necessary in the 24/7 news cycle.

Go Canes!!!

curious - where do you live?
 
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curious - where do you live?
If anything is being oversold, it's this pandemic that's being peddled by the media in order to cripple our economy. But you keep on *****ing about so called cures for a so called pandemic that's being spun in whatever direction the talking heads deem necessary in the 24/7 news cycle.

Go Canes!!!
Wow so we will have close to 200,000 people die during what you're calling a "So called Pandemic". I'd hate to see what would happen to us if what you call a real Pandemic happened. :(
 
If anything is being oversold, it's this pandemic that's being peddled by the media in order to cripple our economy. But you keep on *****ing about so called cures for a so called pandemic that's being spun in whatever direction the talking heads deem necessary in the 24/7 news cycle.

Go Canes!!!

Kinda sad(!) that Trump is so gullible and weak to fall for a media peddled conspiracy to destroy the American economy then, huh? I'm just amazed that Boris Johnson is in on it too! Well played, George Soros. Well played!
 
Loved Milli Vanilli as a kid and still do to this day.

I don’t care who was singing it , that **** sounded great and the writing was good too. I used to lay on the floor as 10 year old and listen to that tape front to back
 
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In spite of the best efforts of the FDA, this well-proven, very safe drug for malaria - hydroxychloroqine - has been proven safe for decades in treating lupus, and rheumatoid arthritis.

So, the treatment that will kill this crap is getting a run - and will be approved all across the US as a viable treatment very soon - and we're going to get back to business.

The deal is - even if you catch it - not a problem. Take your hydroxychloroqine - and drive on!

Give it two more weeks, and this coronavirus will drop out of the limelight faster than burdschitt drops in a downdraft.

Bank it.
Sorry to be the bearer of bad news, but Plaquenil has proven helpful, but it is far from a "cure." Have young people on vents still dying regardless of being on Plaquenil and Azithromycin. We have even started hitting them with biologics like Tocilizumab in order to suppress Cytokine storm and ease the bodies response. It is still hit or miss unfortunately.
 
Sorry to be the bearer of bad news, but Plaquenil has proven helpful, but it is far from a "cure." Have young people on vents still dying regardless of being on Plaquenil and Azithromycin. We have even started hitting them with biologics like Tocilizumab in order to suppress Cytokine storm and ease the bodies response. It is still hit or miss unfortunately.

You'll note I also said that large IV doses of ascorbic acid will reverse this virus - short of death.

They don't want this examined very much - it just happens to kill every single virus it's been used against. Doctors have cured every patient of polio in the 1940's with it. Just kills viruses. And it's not medicine - simple biophysics.

This gets out in the medical community - biological warfare is over. And all those mega-millions of dollars/billions of dollars that come with it.

And without viral epidemics, pandemics, etc., there would be no need for the WHO as is - nor the CDC - as is. And it would gut the FDA control over many aspects of medicine.

It's there for the taking. Ascor, the data, and few takers, as they'll lose their license for using an unapproved biophysics based treatment.

So. Folks die. Unnecessarily.
 
Sorry to be the bearer of bad news, but Plaquenil has proven helpful, but it is far from a "cure." Have young people on vents still dying regardless of being on Plaquenil and Azithromycin. We have even started hitting them with biologics like Tocilizumab in order to suppress Cytokine storm and ease the bodies response. It is still hit or miss unfortunately.

Obviously not a cure.

What do you think of P&Z as prophylaxis? Example: 68 yr old man with comorbidity, quick tests positive. Fever of 101, mild dry cough, headache, not hospitalized, not critical at present time.
 
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In spite of the best efforts of the FDA, this well-proven, very safe drug for malaria - hydroxychloroqine - has been proven safe for decades in treating lupus, and rheumatoid arthritis.

So, the treatment that will kill this crap is getting a run - and will be approved all across the US as a viable treatment very soon - and we're going to get back to business.

The deal is - even if you catch it - not a problem. Take your hydroxychloroqine - and drive on!

Give it two more weeks, and this coronavirus will drop out of the limelight faster than burdschitt drops in a downdraft.

Bank it.
Yeah, and he's got some Steaks for ya too. Maybe stay in his failed casino.
 
Obviously not a cure.

What do you think of P&Z as prophylaxis? Example: 68 yr old man with comorbidity, quick tests positive. Fever of 101, mild dry cough, headache, not hospitalized, not critical at present time.
Since the FDA still hasn't officially cleared P&Z for use against COVID-19, we are only administering this combo inpatient for those that are moderate to severe risk and in PCU or ICU that way we can more closely monitor their clinical progression. Plaquenil has a lot of side effects in those with co-morbidities, specifically it hits the kidneys and your liver pretty hard. Some folks can't tolerate the therapy due to elevated liver enzymes and worsening kidney function through acute kidney injury to their already chronic condition. I wouldn't prescribe this combo for folks in the outpatient setting because in those cases, the person is likely able to successfully fight off the infection and develop antibodies to the virus on their own with only self limiting symptoms.

Of interesting note is the change in practice guidelines regarding early intubation to stave off Acute Respiratory Distress Syndrome and end organ involvement in more severe cases. I hate to say it, but folks have done very poorly on ventilators, with more than 50% not making it off the vent. The thought process now is to delay intubation as long as possible and try to manage with P&Z as well as corticosteroids and biologists to help mitigate cytokine storm, nasal cannula and/or simple mask for oxygenation. We have received feedback and lessons learned from Europe, China, and the East Coast regarding treatment modalities as more information and research has been completed.
 
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Since the FDA still hasn't officially cleared P&Z for use against COVID-19, we are only administering this combo inpatient for those that are moderate to severe risk and in PCU or ICU that way we can more closely monitor their clinical progression. Plaquenil has a lot of side effects in those with co-morbidities, specifically it hits the kidneys and your liver pretty hard. Some folks can't tolerate the therapy due to elevated liver enzymes and worsening kidney function through acute kidney injury to their already chronic condition. I wouldn't prescribe this combo for folks in the outpatient setting because in those cases, the person is likely able to successfully fight off the infection and develop antibodies to the virus on their own with only self limiting symptoms.

Of interesting note is the change in practice guidelines regarding early intubation to stave off Acute Respiratory Distress Syndrome and end organ involvement in more severe cases. I hate to say it, but folks have done very poorly on ventilators, with more than 50% not making it off the vent. The thought process now is to delay intubation as long as possible and try to manage with P&Z as well as corticosteroids and biologists to help mitigate cytokine storm, nasal cannula and/or simple mask for oxygenation. We have received feedback and lessons learned from Europe, China. and the East Coast regarding treatment modalities as more information and research has been completed.

Thanks very much for the detailed response. Are you guys adding anything like low dose prednisone and/or tacrolimus?
 
Thanks very much for the detailed response. Are you guys adding anything like low dose prednisone and/or tacrolimus?
Not in the inpatient setting. We usually go with higher dose solu-medrol IV instead of oral prednisone. In the outpatient setting for conditions like COPD exacerbation or asthma exacerbation, it is standard practice to give a steroid taper of prednisone orally. Also of note, there is very promising evidence concerning plasma infusions from recovered COVID-19 patients. Initial preliminary studies in several hospitals around the nation to include UCLA, Mayo clinic, and the NY health system has shown that infusing plasma from recovered COVID patients to severely or critically ill patients has led to significant improvement in the status of those sick patients to include vast reduction in viral load, clearing of pulmonary infections evidenced by CT scans of the chest or chest xray, as well as laboratory data. This would provide these critical patients with the necessary antibodies needed to fight the virus specifically, while we can also work on tampering down the immune response so it doesn't lead to a run-away cascading response, which has ultimately killed many patients. I think this will be the way to go for severe to critical patients until a vaccine can be developed and proliferated to the masses.
 
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