It would primarily come down to:
1) their DL against our OL. If our RBs continued to really block hard & our TEs helped our OTs, we could hang with them;
2) tackling really well against a physical team;
3) Enos opening up the playbook & not being conservative (which would result in a loss as they would crowd the box & make things really hard for us); and
4) making FGs.
If Duke hung with them for a half, there's no reason we couldn't but the team & the City would have to really bring it.
Your point No. 2 above. Miami faced Wisconsin TWICE and was out muscled in the trenches! Ouch. So this is one lone wacko that says no to a possible meeting with Lord Saban's nasty squad.