Reading that effects can be felt starting st 1500m above sea level. Boone sits at about 1000m.
But also read that in running, NCAA make allowances for race results at altitude. "When attempting to qualify for a 10K championship race, for example, in Boone, NC (3,300’), collegiate men receive a 30 second adjustment; in Boulder, CO (5,200’), the allowance is 64 seconds; 10,000 meters on Northern Arizona University’s track in Flagstaff, AZ, (6,900’) is given a 99 second improvement; and while in Gunnison, CO (7,700’), runners lop off two full minutes from their posted time."