Center, LT, and DT is my answer.
Center makes the blocking calls on the line he is the QB of the O-line. It is a tough position to play physically as not only do you have to deal with snapping the ball but that second gives a DT/NT time to push your face into the dirt if you aren't explosive enough. And then there's inside blitzes, which the center oftentimes has the responsibility to pick up.
LT has a **** ton of blocks and adjustments to make, not to mention they usually deal with the best DE on the team and of course LB/DB blitzers. There is a reason why LT's get paid second only to QB's in the NFL.
DT also has to know their gap assignments, but IMO DT is more about being physically ready.