I was always a big fan, going back before Miss State, because I tend to like Zone Blitz and Fire Zone concepts. Less now, as I liked them more before the proliferation of all of these spread teams and the precision passing games, of course.
Manny needs specific player types to do what he wants to do. Different than D'Ono in that the players don't need to be brutally large or powerful (which I find to be an odd fit for the modern college game), but the same as D'Ono in that, in theory, if he has those types (in his case, DE/OLBs), he'll get excellent results. He puts a lot of pressure on certain positions, so that's very similar to what we're seeing now. The distinctions are large: he errs on the side of aggression. His concepts work better with the type of talent we recruit and have access to. The pressure he puts on positions tends to be on athleticism and processing info. He probably belongs in the NFL, if he plans to stick with that theory.
I've changed my perspective some over the past 10 or so years in that I don't think you need as much complexity at the college level. 10 years ago, when you had a decent idea of what you were facing on offense and offensive styles/rules were somewhat different, defenses had to gain a competitive advantage through disguise. Now, with defenses inherently on their heels because of offensive styles/rules, the best way to allow your players to be aggressive is through relative simplicity. Relative simplicity doesn't mean predictability. It means you have athletes who don't necessarily have to process as much information as they do in the professional game (NFL).
Manny will need to adjust his concepts and get those specific DE/OLB types to execute his system. I'd take him over D'Onofrio because I'll take aggression over conscious passiveness any day.