I can see Mesidor early in the season until the young guys can fully take over but by mid season we should only see Malik Bryant, Marquise Lightfoot, and Booker Pickett Jr. playing Jack.
Here is how I see it based on how Hetherman used his guys at Minnesota.
4i Rueben Bain
4i Armondo Blount and Akheem Mesidor
4i Cole McConathy
NT Ahmad Moten
NT Artavius Jones
NT Donta Simpson
DT David Blay Jr.
DT Justin Scott
DT Akheem Mesidor and Daylen Russell
Jack Marquise Lightfoot
Jack Malik Bryant
Jack Booker Pickett Jr.