I'll break it down.
Against 21/12 personnel and short yardage/run first situations we will favor the traditional 4-3 package. Pass first situations will elect the Striker Package
Against 11 personnel, our NASCAR/Nickel package will be favored, so we can match 3 CB's with 3 WR's and retain a single high safety, with a rover to play with, or 2 safeties high. We want to avoid having 3 LB's in against a 3WR set, which is why we can also elect to play the Striker package against 11-Personnel where the offense has a "Run first" identify or RPO scheme.
Against 4 wide, we would probably end up playing our Nickel package, and have Redwine lined up at Safety still, but more than likely responsible for the 4th WR.
Seems as if the OP is asking if we will elect to a Dime package to combat the 4-wide. This would require running a 3-2-6, or 4-1-6. I don't think our defense would want to run either of those. Outside of a prevent defense, I don't think we will see our squad line up with 6 DBs.
As a counter argument...I would love to see Ed be bold enough to pull a RB and TE off QB protection duties pre-snap. I'm 90% sure Barrow would see 6 rushers and be forced to make a quick decision everytime.
Edit: To answer the question that I think you had, If we some how end up with 6 DBs on the field (which I doubt), I think they would retain Shaq (cuz you need your ILB) and put in Blades as a Dime CB and Bandy as the Nickel. Obviously Dean/Jackson on the outside with Redwine/Jaq in the back.