Places to go in Greenville/Clemson area:
1. The Smokin' Pig (EASLEY) - The Clemson location of this joint has been featured on many shows, including College GameDay, but do yourself a favor and go to the one in Easley. It is much larger and easier to get a table. This location is right off of US 123 between Greenville and Clemson. They bring you cracklins instead of bread. One of my 2 favorite BBQ joints in the area, this one is more of a sit-down restaurant.
2. Smoky Dreams - Woodruff Road, near the Five Forks area. I love love love this place, it's a tiny joint that has an outside smoker, a mix of indoor and outdoor seating, and a takeout window. Amazing stuff and a nice variety of sauces. Only open 4 days a week, and is right next to a McDonalds, so don't drive past it.
3. Bacon Brothers Public House - Pelham Road and 85, near the airport. The name says it all. The owners and chefs are very creative, the name kinda says it all, a nice variety of meats (particularly bacon). A bit more of a combo bar/restaurant, this place is usually crowded.
4. Saskatoon Steaks, Fish and Wild Game - Haywood Road, about a mile south of the mall. Again, the name describes the place, they have a very wide assortment of wild game meat that you just won't be able to find in any other restaurants. Big, beautiful building, nice bar, great food. A little fancy, but not formal.
5. Smoke on the Water - another BBQ place, fancier, in the downtown area. Very scenic. If you have the time, try to walk around downtown Greenville during the day, it is beautiful along the river.
6. White Duck Taco Shop - OK, this one is a bit hard to find, so bear with me. There is an old industrial area right off the railroad tracks that has been gentrified into breweries and eateries. You have to drive north on Pete Hollis Blvd, cross over the railroad tracks, and then hang a couple of lefts back towards the railroad tracks. This taco spot is worth the drive and effort, but make sure you use Google Maps to find it.
7. For the Cubans in the crowd, Mad Cuban Cafe (Simpsonville) - near the corner of Fairview Road and Harrison Bridge Road (both roads are exits off of 385), this might be the only Cuban spot in the whole area, but it is surprisingly good. Not fancy, but they do good Cuban sandwiches and they will add stuff to the sandwich before pressing. I would get the Cuban and add plantains and croquetas.
8. Stella's Southern Bistro (Simpsonville) - across Fairview from Mad Cuban Cafe, this place is fantastic. A bit fancy, but it's stlll Southern food. Come on now.
9. Stax Omega Diner & Bakery - near Haywood & Pelham, this place is fantastic for breakfast and is usually packed.
10. Sidewall Pizza Company - this is a local chain, but it's **** good, I usually went to the one on Pelham by Bacon Brothers.
There are a bunch of good places in downtown as well. If you are interested in any other spots, just ask.