Urban Meyer said it best, the run game is a numbers game.
Football in itself is a numbers game. Runs into light boxes are more likely to succeed compared to condensed and stacked boxes. Matchups mater, field condension and distribution of players, angles of routes and distances, all of this matters.
Bill Walsh drew up plays designed at some point that he was looking for triangular patterns between the routes to put zone and read defenders in rat coverages into a blend. Its in his book, I have it as a PDF and its just nuts to read.
When I watch College Football, successful offenses make the field feel as if its 25 kilometres wide. The cameras have to zoom out because they want to show the line of scrimmage every play with every player involved. Miami makes the field look small in contrast.