My favorite in-game commentary was on NCAA 06 or 07 where if the ball carrier would break free for a long run you'd hear the announcer say, "he's got get away from the cops speed."
Madden 04 where they introduced QB vision was great. Manning's vision was the entire god**** field.
Having your team get put on probation due to to many infractions or players miss games because of academic issues was to funny.